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KMID : 0369319920120040528
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Allergy
1992 Volume.12 No. 4 p.528 ~ p.534
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a Comparison of Salmeterol with Salbutamol in the treatment of patients with Mild to Moderate Reversible Bronchial Obstruction
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이상표
김봉식/박인원/최병휘/허성호
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Abstract
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Salmeterol is a novel beta-2 adrenoreceptor fours. We compared the efficacy and safety of a new long acting inhaled beta-2 adrenoreceptor agonist, salmeterol, with a short acting peta-2 agonist, salbutamol, in the treatment of mild to moderate
bronchial
asthma.
We randomly assigned 60 patients (38 male and 22 female patients, 16 to 72 years old) to one of two treatment groups: One group received 50㎍ of Salmeterol twice daily, and another received 200㎍ of salbutamol four times daily.
The study was perfomed as an open-label and the 6-week treatment period was preceded by a two 1-week treatment run-in period.
@ES The results were as follows:
@EN 1) Day-time symptonr score showed significant difference between salmeterol and salbutamol group(p<0.05), but there were no significant differences in night time symptom score and precentage of days with symptom score 0 between two groups.
2) There was no significant differences in the number of days required for additional bronchodilator but the number of puffs for additional bronchodilator was lower in the salmeterol group at day time(p<0.05).
3) Six weeks after salmeterol treatment, PEFR showed significant increase in both day and night time than salbutamol group(p<0.05).
4) Both groups showed no significant change in the percentage of FVC after 6 weeks treatment period.
5) In salmeteerol group FEV1 showed significant incease(p<0.05) than salbutamol group after 2 and 4 weeks treatment period.
6) There was no adverse reactions requiring to quit the salmeterol during treatment.
In conclusion, salmeterol given twice daily would be superior to salbutamol given four times a day for the management of mild to moderate bronchial asthma.㎍
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KEYWORD
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